Author's Organization：Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University Institute of Pharmaceutical Sciences, Faculty of Medicine, Kyushu University
The urinary metabolic end-products of meprobamate (2-methyl-2-propyl-1, 3-propanediol dicarbamate) in rabbits and dogs were studied. They were isolated and characterized as keto-, hydroxy-, carboxy-meprobamate and three glucuronides containing carbamate group, but in dogs keto-and carboxy-derivatives were not isolated. Of glucuronides, one was N-glucuronide conjugated with meprobamaet itself and another was ethertype glucuronide of hydroxy-meprobamate.
