Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Potential Antimetabolites. IV. Synthesis of 2, 6-Bis-alkylthiopurine Ribosides and their Selective Substitution by Nucleophilic Reagents
Morio IkeharaTohru UedaSumiko HorikawaAkihiro Yamazaki
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1962 Volume 10 Issue 8 Pages 665-669

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Abstract
2, 6-Bis-methylthio-and 2, 6-bis-benzylthio-9-(2', 3', 5'-tri-O-benzoyl)-β-D-ribofuranosylpurines were synthesized by the condensation of chloromercury salt of 2, 6-bisalkylthiopurines with 2, 3, 5-tri-O-benzoyl-D-ribofuranosyl chloride. The transformation to 6-dimethylamino-and 6-methylamino-9-β-D-ribofuranosylpurine by the successive amination and desulfurization was achieved.
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© The Pharmaceutical Society of Japan
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