Antiviral Effect and Syntheses of 4-Amino-6-alkylamino-s-triazine-2-carboxylic Acid Derivatives. Researches on Chemotherapeutic Drugs against Viruses. XXXVI.
New compounds of 4-amino-6-alkylamino-s-triazine-2-carboxylic acid and N-amidino-4-amino-6-alkylamino-s-triazine-2-carboxamide were synthesized from 1-alkyl-3-(4, 5-dioxo-2-imidazolidinylidene) guanidine prepared by condensation of 1-alkylbiguanide with diethyl oxalate and examined as to their antiviral effect. Among these compounds, N-amidino-4, 6-diamino-s-triazine-2-carboxamide was found to possess an inhibitory effect on polio virus.
