Studies on Digitalis Glycosides. XVII. Transformation of Cardenolides by Microorganisms. (3). 1β, 7β-Dihydroxy-digitoxigenin and 5β, 7β-Dihydroxydigitoxigenin.
The structure and configuration of two kinds of dihydroxyl derivatives obtained by microbiological transformation of digitoxigenin with Absidia orchidis were discussed. One of them was shown to be 1β, 7β-dihydroxydigitoxigenin and the other 5β, 7β-dihydroxydigitoxigenin. This represents the first instance of the introduction of two hydroxyl groups into a cardiac aglycone by microbial oxidation.
