Syntheses of Pyridazine Derivatives. III. 4-or 5-Chloro-3, 6-dimethylpyridazine 1-Oxide.

Abstract

N-Oxidation of 4-chloro-3, 6-dimethylpyridazine (II) with monoperphthalic acid gave 4-chloro-3, 6-dimethylpyridazine 1-oxide (III) and 5-chloro-3, 6-dimethylpyridazine 1-oxide (IV). The order of reactivity of these chloro-compounds in nucleophilic substitution are IV>II>III.