Abstract
Nitration of pyridazine 1-oxide (I) with acyl nitrate afforded two kinds of β-nitropyridazine 1-oxide, i. e., 3-nitropyridazine 1-oxide (III) as a main product and 5-nitropyridazine 1-oxide (IV) as a poorly yielded by-product. Structural correlations of those nitro compounds to known pyridazine derivatives were achieved by catalytic hydrogenations or nucleophilic displacement reactions of the active nitro group. Furthermore, some nucleophilic substitution reactions of III and 3-chloropyridazine 1-oxide were described.
