Studies on Steroids. II. The Preparation and Properties of 17β-(N-Substituted 2-Amino-4-thiazolyl) androst-4-en-3β, 17α-diol Series and its Hydrogen Succinate.

Abstract

17β-(2-alkylamino-(or 2-arylamino-or 2-N, N-alkylarylamino-) thiazolyl) androst-4-en-3β, 17α-diol was prepared from corresponding 3-one with sodium boronhydride in dioxan or dioxane-methanol (1 : 1). 17β-(2-alkylamino-(or 2-arylamino-)-4-thiazolyl) androst-4-en-3β, 17α-diol 3-(hydrogen succinate) and O, N-bis(hydrogen succinate) were obtained from corresponding 3β, 17α-diol and 17α-ol-3-one with succinic anhydride. Some of this substance had a digitalis like properties.