Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Acetylenic Compounds. XXXI. Intramolecular Cyclization Reaction of the Acetylenic Compounds.
Issei IwaiTetsuo Hiraoka
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1963 Volume 11 Issue 5 Pages 638-643

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Abstract

Intramolecular condensational cyclization of the acetylenic compounds to the aromatic nucleus was achieved with polyphosphoric acid, and this reaction was accompanied with dehydrogenation to give naphthalene derivatives. This method can also be used to nitrogen containing acetylenic compounds to prepare carbostryril derivatives.

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© The Pharmaceutical Society of Japan
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