Studies on the Metabolism of Sulfathiazole. IV. A New Sulfathiazole-glucuronic Acid Conjugate in the Human Urine.

Abstract

A new glucuronide of sulfathiazole was isolated from human urine after administration of sulfathiazole. This glucuronide was isolated as its ammonium salt with melting point 176∼178°(decomp.). It was confirmed that the conjugate is sulfatiazole-N¹-glucuronide by the data of ultraviolet and infrared spectroscopy.