Abstract
4-Nitroquinoline 1-oxide and related compounds react easily with SH-group of thioglycolic acid affording the corresponding sulfides of these compounds. With these nitro compounds, the present authors studied the nucleophilic substitution reaction between 4-nitro group and thioglycolic SH-group, and determined the reaction rate constants, energies of activation and entropies of activation in several kinds of solvent system. On the other hand, 4-nitroquinoline 1-oxide and some related compounds have been known to be skin cancer producing agents. Then, the chemical activity of 4-nitro groups which were obtained were discussed on comparison with the carcinogenic activity.
