Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on Acetylenic Compounds. XXXIII. A New Synthetic Method for Aminoacetylenic Compounds.
Issei IwaiYasuo Yura
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1963 Volume 11 Issue 8 Pages 1049-1054

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Abstract
A new and convenient route for the synthesis of various kinds of aminoacetylenes has been devised with Grignard reaction of aminoethers using acetylenemagnesium bromide. In the various cases examined, the yields range was 26∼76%. Both N, N-di (2-propynyl) amine- an 1, 4-di (2-propynyl) piperazine derivatives could be produced by this reaction, but in latter N, N-di (2-propynyl) methylamine derivative due to low reactivity of N, N-bis (butoxymethyl) methylamine (III) the reaction time was prolonged. Furthermore, by this reaction acetylenic aminoalcohols were obtained from cyclic aminoethers.
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© The Pharmaceutical Society of Japan
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