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Volume 11, Issue 8
Displaying 1-27 of 27 articles from this issue
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Morio Ikehara, Eiko Ohtsuka1963 Volume 11 Issue 8 Pages 961-967
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSP-Diphenyl P'-morpholino pyrophosphorochloridate was prepared from morpholino phosphorochloridate and diphenylphosphate and used for the phosphorylation of isopropylidene-adenosine, -uridine, -N6-dimethyladenosine and 9-(4'-hydroxybutyl) adenine. AMP, UMP, N6-dimethyl-AMP and 9-(4'-hydroxybutyl) adenine 4'-monophosphate was obtained in 33∼60% isolated yield. By the reaction of products obtained in the phosphorylation of 2', 3'-di-O-acetyladenosine and 3'-deoxythymidine with this reagent, with pyrophosphate salt, ATP and 3'-deoxythymidine 5'-triphosphate were synthesized in good over-all yield.View full abstractDownload PDF (811K) -
Tsutomu Momose, Yoshiko Yano, Katsuko Ohashi1963 Volume 11 Issue 8 Pages 968-972
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAqueous sodium tungstate and alum were successfully used in the deproteinization of blood or serum to determine the sugar value with 3, 6-dinitrophthalic acid. They were easily prepared and preserved, and fitted for clinical tests. The deproteinizing agent could also be used in a powdered state.View full abstractDownload PDF (512K) -
Tsutomu Momose, Yosuke Ohkura, Kazuya Kohashi, Reiko Nagata1963 Volume 11 Issue 8 Pages 973-977
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe sum of acetone and acetoacetic acid in blood was successfully determined with trinitrobenzene as the color developing agent. The method is simple to carry out with a large number of samples, and gives reproducible results.View full abstractDownload PDF (568K) -
Masao Nishikawa1963 Volume 11 Issue 8 Pages 977-985
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe infrared spectra of halocyclohexanes and trans-1, 2-dihalocyclohexanes trapped in thiourea channels were investigated by the use of the technique developed in the previous paper. It was revealed that these compounds took preferably the axial conformation of the C-X bond in thiourea channels. The abundance ratio of the two conformational isomers is found to depend upon the size and shape of these molecules and of the space provided by thiourea framework. From these results the bands attributable to the axial isomer were assigned definitely and the assignment made by previous workers was partly revised. The mobility or the orientation of these guest molecules in channels was also discussed and the dynamic equilibrium between the axial and equatorial conformations was proved in the case of halocyclohexanes.View full abstractDownload PDF (896K) -
Hiroshi Kugita, Mikio Takeda1963 Volume 11 Issue 8 Pages 986-989
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS9-Hydroxymethyl-2, 5-dimethyl-6, 7-benzomorphan has been synthesized by hydroboration reaction of 9-methylene-2, 5-dimethyl-6, 7-benzomorphan. Configuration of the newly introduced 9-hydroxymethyl group was confirmed as trans with 5-methyl group for the hydroaromatic ring.View full abstractDownload PDF (559K) -
Shigeharu Inouye1963 Volume 11 Issue 8 Pages 990-999
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS1. Structural information concerning to the binding states of crystal water, complexing agent and sulfate anion in the dα and hγ crystals are deduced from the spectral changes accompanied with partial dehydration, together with X-ray evidence. The findings include the mobility or statistical disorderness of crystal water in the dα form, and the presences of little bonded water and a monomeric complexing agent in the hγ form. 2. From the intense band near 1100cm-1 observed in all the dα crystals, it is concluded that Td symmetry of sulfate anion still holds in the dα form. The different magnitude in splitting of the sulfate band among the hγ crystals is interpreted in terms of the removal of vibrational degeneracy of v3, as a result of interaction of a sulfate anion with a complexing agent. 3. The spectral differences arising from polymorphism are shown in the cases between the dα and dβ forms and between the hγ and hδ forms.View full abstractDownload PDF (994K) -
Kozo Nagano, Hisashi Kinoshita, Zenzo Tamura1963 Volume 11 Issue 8 Pages 999-1013
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSConsecutive formation constants of metal complexes of isonicotinoylhydrazine (INH) and related compounds were determined by the pH titration method. The calculation was performed by an electronic computer applying the iterative approximation method from the data of titration curves of various ratio of ligand to metal ion, pKa values of ligands, and hydrolysis constants of metal ions which were also determined by pH titration. The constants thus obtained for 1 : 1 complexes and chelates were plotted against the pKa values, and some interesting relationship suggesting the reaction mechanism of complex formation were found.View full abstractDownload PDF (1029K) -
Morizo Ishidate, Zenzo Tamura, Keijiro Samejima1963 Volume 11 Issue 8 Pages 1014-1021
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe biliary excretion of DAB metabolites was first examined by paper chromatography, colorimetry, and by other methods. Presence of a selectivity in rat liver was recognized such as the main excretion of DAB metabolites retaining the azo bond into the bile and seven kinds of DAB metabolites (AB, 4'-OS-DAB, 4'-OS-MAB, 4'-OS-AB, 4'-OG-MAB, 4'-OG-MAB, 4'-OG-AB) were identified. Second, influence of DAB feeding on the amount of these seven kinds of DAB metabolites was examined by the method of newly devised separatory determination using DEAE ion-exchanger and other methods. The most appropriate explanation for the results obtained was the promotion of hydroxylation in the first and middle stages of DAB feeding, although there were yet several problems.View full abstractDownload PDF (824K) -
Kyosuke Tsuda, Shigeo Nozoe, Yutaka Okada1963 Volume 11 Issue 8 Pages 1022-1027
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSBromination of 3-methoxy-9 (11)-dehydroestrone (II) gave equilenin methylether (IV). Hydroxybromination of 3-acetoxy-9 (11)-dehydrostrone (III) with N-bromosuccinimide in the presence of perchloric acid afforded a bromohydrin (VI), whose structure was assigned 3, 9α-dihydroxy-11β-bromoestra-1, 3, 5 (10)-trien-17-one 3-acetate, on the basis of the resistance of hydroxyl group to acetylation and oxidation, and by leading to 9α, 11α-epoxide (VII) and triol (IX).View full abstractDownload PDF (753K) -
Junnosuke Suzuki, Kyosuke Tsuda1963 Volume 11 Issue 8 Pages 1028-1033
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSEs wird die Photooxydation von 7-Dehydrocholesterin-acetat beschrieben. Als neues Reaktionsprodukt laβt sich 3β-Acetoxychlolesta-5, 8 (9)-dien-7-on gewinnen. Bei der thermishen Umlagerung von 3β-Acetoxycholest-6-en-5, 8α-epidioxyd ergibt sich neben den bekannten Produkten noch eine neue Verbindung, namlich 5, 6α-Epoxy-cholest-8 (14)-en-3β, 7α-diol-3-acetat, die sich nach ublicher Methode in 3β-Acetoxycholesta-5, 8 (14)-dien-7-on uberfuhren laβt.View full abstractDownload PDF (750K) -
Shigeo Iwasaki, Kyosuke Tsuda1963 Volume 11 Issue 8 Pages 1034-1036
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSEs wird die Photooxydation von Ergosterin beschrieben. Dabei laβt sich als Nebenprodukt ein 5, 8-Dien-7-on gewinnen. Zur Verbesserung der Ausbeute von 5, 8-Dien-7-on werden verschiedene Losungsmitteln untersucht.View full abstractDownload PDF (477K) -
Hiroko Hasegawa, Shigeo Nozoe, Kyosuke Tsuda1963 Volume 11 Issue 8 Pages 1037-1041
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe reduction of 3-hydroxy-9α, 11α-epoxyestra-1, 3, 5 (10)-trien-17-one (III) with lithium aluminum hydride gave estra-1, 3, 5 (10)-triene-3, 11α, 17β-triol. The reaction of III with hydrogen chloride in methanol yielded 3-hydroxy-9β-estra-1, 3, 5 (10)-triene-11, 17-dione (IXa). On the other hand, the reaction in chloroform afforded 9ξ-chloro-3, 11α-dihydroxyestra-1, 3, 5 (10)-trien-17-one (VIIIa). With alkali 3-hydroxyestra-1, 3, 5 (10)-triene-11, 17-dione (Va) is converted into 9β-isomer (IXa).View full abstractDownload PDF (627K) -
Issei Iwai, Junya Ide1963 Volume 11 Issue 8 Pages 1042-1049
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThis is a new synthetic method for various 4-substituted-3-chromenes : phenyl propargyl ethers underwent intramolecular cyclization to give 4-chromene derivatives by heating with diethylaniline. The reaction mechanism was clarified by the study of substituted phenyl propargyl ethers under the consideration of their electronic effects on the yields of resulting 3-chromene ; in general, the presence of +R group enhanced the cyclization, whereas -R group gave much lower yields of the corresponding chromenes. Therefore, this intramolecular cyclization is concluded to be an electrophilic reaction.View full abstractDownload PDF (849K) -
Issei Iwai, Yasuo Yura1963 Volume 11 Issue 8 Pages 1049-1054
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA new and convenient route for the synthesis of various kinds of aminoacetylenes has been devised with Grignard reaction of aminoethers using acetylenemagnesium bromide. In the various cases examined, the yields range was 26∼76%. Both N, N-di (2-propynyl) amine- an 1, 4-di (2-propynyl) piperazine derivatives could be produced by this reaction, but in latter N, N-di (2-propynyl) methylamine derivative due to low reactivity of N, N-bis (butoxymethyl) methylamine (III) the reaction time was prolonged. Furthermore, by this reaction acetylenic aminoalcohols were obtained from cyclic aminoethers.View full abstractDownload PDF (699K) -
Masaaki Horiguchi, Nobuyuki Higosaki, Tadahiro Iwashige, Issei Iwai1963 Volume 11 Issue 8 Pages 1055-1058
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSGas liquid partition chromatography has been applied to twelve derivatives to separate the anomeric mixtures of 2, 3-anhydro-D-ribofuranoside and 2, 3-anhydro-D-lyxofuranoside under several operating conditions. The relation between retention times, their structures and substituents were observed.View full abstractDownload PDF (464K) -
Takanobu Itai, Shozo Kamiya1963 Volume 11 Issue 8 Pages 1059-1064
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSReaction of 3, 4, 5-trichloropyridazine (IV) with sodium methoxide was examined. 4-Azidopyridazine 1-oxide (XVII) and 5-azidopyridazine 1-oxide (XXI) were synthesized from corresponding hydrazino compounds (XIV, XX) with nitrous acid, and XVII was also derived from 4-chloropyridazine 1-oxide (XIII) with sodium azide.View full abstractDownload PDF (764K) -
Shojiro Uyeo, Takanori Hayazaki, Haruaki Yajima1963 Volume 11 Issue 8 Pages 1065-1067
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTazettine was oxidized with chromic acid under the controlled conditions to give a neutral compound, oxotazettine, C18H19O6N·1/2H2O, which was shown to be represented by the formula (II).View full abstractDownload PDF (437K) -
Hideo Sugimoto1963 Volume 11 Issue 8 Pages 1067-1068
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
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Tyunosin Ukita, Hikoya Hayatsu, Yutaka Tomita1963 Volume 11 Issue 8 Pages 1068-1073
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe condensation reaction of acetobromoglucose with chloromercuri-4-ethoxy-2 (1H)-pyrimidinone (I), which had been reported by Fox, et al. to yield 1-(tetra-O-acetyl-β-D-glucopyranosyl)-4-ethoxy-2 (1H)-pyrimidinone (II), was reinvestigated. It was confirmed that the main product of the reaction is not the N-glucoside (II) but the O-glucoside, 2-[(tetra-O-acetyl-D-glucopyranosyl)oxy]-4-ethoxypyrimidine (III). II was obtained as a minor product of the reaction. The O-glucoside (III) was converted to the N-glucoside (II) by the action of mercuric bromide in boiling xylene in a yield of 30∼40%. This transglycosidation reaction was followed by ultraviolet absorption spectrum and by the yield of II isolated from the reaction mixture. A direct synthesis of II by the condensation of acetobromoglucose with I in the presence of mercuric bromide was described.View full abstractDownload PDF (707K) -
Takanobu Itai, Shozo Kamiya1963 Volume 11 Issue 8 Pages 1073-1077
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS4-Azido-3, 6-dimethoxypyridazine (X) was synthesized from 4-chloro-3, 6-dimethoxypyridazine (VII) through the hydrazino compound and X was converted to 4-azido-3, 6-dimethoxypyridazine 1-oxide (XII). Besides, some reactions of 4-chloro-3, 6-dimethoxypyridazine 1-oxide (I) and XII were examined.View full abstractDownload PDF (682K) -
Akihiro Ohta, Yukio Ogihara, Kiyoshi Nei, Shoji Shibata, Nobuo Ikekawa1963 Volume 11 Issue 8 Pages 1078-1080
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe gas chromatography of monomethyl-and dimethyl-1-phenylnaphthalenes were carried out. A correlation between the retention time and the position of methyl substitution in 1-phenylnaphthalene nucleus was found.View full abstractDownload PDF (599K) -
Masuo Akagi, Setsuzo Tejima, Masanobu Haga, Masakatsu Sakata1963 Volume 11 Issue 8 Pages 1081-1082
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
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Morizo Ishidate, Michiya Kimura, Meiji Kawata1963 Volume 11 Issue 8 Pages 1083-1084
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
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Eiji Ochiai, Hiroshi Mitarashi1963 Volume 11 Issue 8 Pages 1084-1085
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
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Toshihiko Okamoto, Tadamasa Onaka1963 Volume 11 Issue 8 Pages 1086-1088
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
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Toshihiko Okamoto, Masaaki Hirobe, Yasunobu Tamai1963 Volume 11 Issue 8 Pages 1089-1090
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
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Yoshihisa Mizuno, Morio Ikehara, Kyoichi Watanabe, Shigeo Suzaki1963 Volume 11 Issue 8 Pages 1091-1094
Published: August 25, 1963
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (482K)
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