Studies on Morphine Alkaloids. I. Nuclear Magnetic Resonance Spectral Studies on Morphine Alkaloids. (I).

Abstract

The nuclear magnetic resonance spectra of twenty two morphine type derivatives were measured and their characteristic signals of the aromatic protons, N-methyl, acetoxylmethyl, the ethylenic protons in ring C, the protons alpha to hydroxyl, acetoxyl and C₄-C₅ ether bridge, and those of C_9α, C_10β, and C_14β were assigned. The observed values of J_{5β, 6α} or J_{5β, 6β} and the chemical shifts of C₆-acetoxylmethyl yielded information about the ring C conformation.