Studies on 4-Isopropyl-quinazoline 1-Oxide and 4-Isopropyl-2-quinazolinecarbonitrile.

Abstract

On the study of the 4-isopropylquinazoline 1-oxide, various following reactions were examined in detail. Those results and considerations are given with the reaction formula in the text. 1) N-oxidation of 4-isopropylquinazoline. 2) Reaction with alkali. 3) Reaction with sulfur dioxide or sodium hydrogensulfite. 4) Reaction with hydrogen cyanide or hydrogen cyanide-potassium cyanide. 5) Reaction with Grignard reagent. 6) Reaction with phenyllithium. 7) Reissert reaction. 8) Reaction with benzoyl chloride. 9) Reaction with acetic anhydride. 10) Reaction with phosphorus oxychloride (sulfuryl chloride). 11) Reaction with tosyl chloride. 12) Other reactions. As well as on 4-isopropyl-2-quinazolinecarbonitrile prepaed by the reaction 7), various following reaction are examined in detail. The results are also given. 13) Reaction with methoxide ion. 14) Reaction with hydrazine. 15) Reaction with amine. 16) Reaction with phenylmagnesium bormide. 17) Another reaction.