Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Oxidation with Nickel Peroxide. III. Oxidative Cleavage of α-Glycols, α-Hydroxy Acids, α-Keto Alcohols, and α-Keto Acids.
中川 国夫伊賀野 憲一杉田 実男
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1964 年 12 巻 4 号 p. 403-407

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Solid nickel peroxide, readily obtainable by the treatment of nickel salts with sodium hypochlorite in alkaline solution, has been proved to be an useful reagent for the oxidative cleavage of α-glycols and α-hydroxy acids in aprotic solvents. Some kinds of aldehydes or ketones were obtained in moderately good yield as glycol cleavage products. With nickel peroxide in an aqueous alkaline solution, α-keto alcohols and α-keto acids were transformed into carboxylic acids by the oxidative cleavage.
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© The Pharmaceutical Society of Japan
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