Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Biosynthesis of Skimmianine
松尾 光芳樫田 義彦
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1966 年 14 巻 10 号 p. 1108-1112

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Skimmianine isolated from Skimmia plants fed with anthranilic acid (T), acetate (1-14C), acetate (2-14C) and DL-tryptophan (3-14C) was shown to be radioactive. Degradation of the labeled skimmianine showed that the radioactivity was located in the benzene ring when anthranilic acid (T) was administered, while it was located at the position 3 of quinoline nucleus when acetate (2-14C) or DL-tryptophan (3-14C) was used as the labeled precursors. On the basis of these results, a scheme of the biosythesis of skimmianine was proposed in which skimmianine was shown to be derived from anthranilic acid and acetate.
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© The Pharmaceutical Society of Japan
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