Synthesis of Quinolizine Derivatives. XVI. Synthesis of 3-(Subst.-benzyl)quinolizidine

Abstract

Some kinds of simple quinolizidine derivatives were recently found to possess sparteine-like uterus contracting action and this time the new substance with stronger contracting action has been found. Among 3-(subst.-benzyl)-quinolizidine derivatives, 3-(4-chlorobenzyl)-quinolizidine (Ib) was found to be the strongest. Ib showed several folds of activity to sparteine sulfate both in vitro and in vivo and the toxicity was found to be about one third of it. The synthesis of Ib was carried out according to the two method (1) and (2), the former synthetic process being found to be beneficial.