Investigations on Pantothenic Acid and Its Related Compounds. IV. Chemical Studies. (3). Syntheses of D-Pantetheine 4'-Phosphate and N-D-Pantothenoyl-L-cysteine 4'-Phosphate

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D-Pantetheine 4'-phosphate (VIa) and D-pantothenoyl-L-cysteine 4'-phosphate (VIb) was prepared by two different routes. The first involved reaction of D-pantothenonitrile 4'-dibenzyl phosphate (II) with cysteamine or L-cysteine followed by acid hydrolysis and then reduction with sodium in liquid ammonia. In the second route, D-pantothenonitrile 4'-phosphate (VII) was treated with cysteamine or L-cysteine to form thiazoline (VIII), which was then hydrolyzed.