Studies on Pyrimidine Derivatives and Related Compounds. XLVII. Reaction of Thiamine with Dialkyl Acylphos-phonates or Methyl Phenylacyl-phosphinates : Takamizawa Reaction 6

Abstract

Several kinds of dialkyl acylphosphonate (IIIa∼d, Va∼d) were synthesized and reacted with thiamine to give 1, 6-dihydropyrimido [4', 5'-4, 5] pyrimido [2, 3-c] [1, 4] thiazine derevatives (XIIA, B, XIIIA, B). Methyl phenylacylphosphinate also gave same result.