Chemical and Pharmaceutical Bulletin

Studies on the Proton Magnetic Resonance Spectra in Aromatic Systems. II. Discussions on the Polysubstituted Benzene Derivatives.

Yoshio Sasaki, Miyoko Suzuki, Akiko Shimazu, Atsuko Misaki

1967 Volume 15 Issue 8 Pages 1083-1087
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1083

JOURNAL FREE ACCESS

Show abstractHide abstract

The reliability and limitation on the simple sum rule of the shielding parameters in polysubstituted benzene series have been discussed and the ring proton chemical shifts for several systems have been estimated from the above parameters.

View full abstract

Download PDF (478K)
Studies on Cinnolines. V. Cinnoline Dioxide.

Ikuo Suzuki, Masahiro Nakadate, Toshiaki Nakashima, Natsuko Nagasawa

1967 Volume 15 Issue 8 Pages 1088-1094
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1088

JOURNAL FREE ACCESS

Show abstractHide abstract

Cinnoline dioxide (IV) and indazole (V) were obtained in addition to the monoxides on oxidation of cinnoline (I) with hydrogen peroxide in acetic acid. The structure of IV was confirmed by chemical and physico-chemical methods of UV, IR and NMR spectrometry and by polarographic reduction.

View full abstract

Download PDF (875K)
Biochemical Studies on Quinone Derivatives. II. Effects of Naturally Occurring Benzoquinone Derivatives on the Respiration of Intact Rat Liver Mitochondria.

Hikaru Ozawa, Kazutaka Momose, Shinsaku Natori

1967 Volume 15 Issue 8 Pages 1095-1100
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1095

JOURNAL FREE ACCESS

Show abstractHide abstract

Effects of naturally occurring benzoquinone derivatives on rat liver mitochondrial respiration were examined manometrically and polarographically comparing with ubiquinone-0. Dihydroxythymoquinone, helicobasidin, and dihydroperezone were found to show significant effect on the respiration. At the concentration of 1.0×10^-5M, dihydroxythymoquinone eliminated the State-3 respiration completely and the for 50% inhibition of the State-3 respiration it required the concentration of 3.2×10^-6M. Helicobasidin was an uncoupler and dihydroperezone showed both an uncoupling action on State-4 respiration and an inhibitory action of State-3 respiration. The other benzoquinone derivatives examined did not show any significant effects on mitochondrial respiration.

View full abstract

Download PDF (620K)
Studies on Antiviral Agents. II. Synthesis and Biological Activity of Maleimide Derivatives.

Hidetaka Yuki, Tadahiro Yamamoto, Yasuo Tohira, Bunya Aoki, Tokio Kano ...

1967 Volume 15 Issue 8 Pages 1101-1106
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1101

JOURNAL FREE ACCESS

Show abstractHide abstract

N-and 2-substituted maleimides were synthesized as antiviral agents. Though all were negative against Adenovirus type 5 and Newcastle disease virus, some compounds were found to be active against certain bacteria and fungi.

View full abstract

Download PDF (579K)
Studies on Antiviral Agents. III. Synthesis of Tenuazonic Acid Derivatives.

Hidetaka Yuki, Yasuo Tohira, Bunya Aoki, Tokio Kano, Shinichi Takama, ...

1967 Volume 15 Issue 8 Pages 1107-1111
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1107

JOURNAL FREE ACCESS

Show abstractHide abstract

Tenuazonic acid derivatives were synthesized from amino acid esters by N-acetoacetylation with diketene followed by cyclization with sodium alkoxides. Some L-amino acid produced a small amount of DL-compounds in this process. N-Acetoacetyl group of diethyl aspartate cyclized to the α-ester group to form five-membered ring compound selectively. These compounds were condensed with carbonyl reagents.

View full abstract

Download PDF (595K)
Studies on Chemical Carcinogens. III. Polarographic Reduction Potentials of Nitroquinoline Derivatives.

Misako Tachibana, Shohei Sawaki, Yutaka Kawazoe

1967 Volume 15 Issue 8 Pages 1112-1119
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1112

JOURNAL FREE ACCESS

Show abstractHide abstract

The polarographic reduction potentials (NO₂→NHOH) were measured of 35 kinds of nitroquinoline derivatives. Discussions were made on the E_1/2 values in connection with their chemical structures.

View full abstract

Download PDF (722K)
Studies on Antiviral Agents. IV. Biological Activity of Tenuazonic Acid Derivatives.

Seikichi Suzuki, Fumihiko Sano, Hidetada Yuki

1967 Volume 15 Issue 8 Pages 1120-1122
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1120

JOURNAL FREE ACCESS

Show abstractHide abstract

Antiviral activity of tenuazonic acid derivatives against adenovirus type 5 was examined. Some compounds showed the significant chemotherapeutic indexes. This antiviral activity was not antagonized by the amino acid from which the test compounds were derived.

View full abstract

Download PDF (432K)
Studies on Antiviral Agents. V. Synthesis and Antiviral Activity of N-Chloro Compounds.

Hidetaka Yuki, Torahiko Kishikawa, Yasuo Tohira, Seikichi Suzuki, Fumi ...

1967 Volume 15 Issue 8 Pages 1123-1128
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1123

JOURNAL FREE ACCESS

Show abstractHide abstract

N-chloro compounds were synthesized and their virus inactivating activity and probable mechanism of the action were investigated. It is likely that the N-chloro compounds oxidize the sulfhydryl groups of the viral protein coat to form disulfide, disulfoxide, and sulfinic acid resulting in inactivation of the virus. This action is nonspecific and irreversible, and is lost in the presence of serum proteins.

View full abstract

Download PDF (634K)
Stereoselective Hydrogenation of Xylenes and Their Tetrahydro Derivatives by a Reduced Nickel Catalyst.

Haruhiko Yamamoto, Hiroyuki Horiguti, Kunio Noda, Takao Kwan

1967 Volume 15 Issue 8 Pages 1129-1137
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1129

JOURNAL FREE ACCESS

Show abstractHide abstract

o-, m-, p-xylene and their tetrahydro derivatives were hydrogenated by a reduced nickel catalyst over the temperature range 150∼250°to investigate the mechanism of the stereoselective formation of cis and trans isomer in vapor phase. The selectivity for the formation of trans isomer was the greatest with p-xylene and the smallest with m-xylene. More than 50% trans isomer was produced with p- and o-xylene but not with m-xylene over the entire temperature range investigated. A similar result was obtained also for the hydrogenation of dimethylcyclohexenes. On the basis of these findings, the Horiuti-Polanyi-Siegel mechanism, as shown schematically in Fig. 6, was discussed taking into consideration various adsorbed types for the half-hydrogenated state. It was shown that the mechanism will meet some difficulties to account for the experimental results. On the other hand, the trans addition of hydrogen to π-allylic adsorbed species giving rise to trans isomer was considered to occur in particular at higher temperatures.

View full abstract

Download PDF (847K)
Effect of Terephthalic Acid upon Sulfadimethoxine Contents in Blood Plasma.

Akio Hoshi, Reiko Yanai, Kazuo Kuretani

1967 Volume 15 Issue 8 Pages 1138-1144
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1138

JOURNAL FREE ACCESS

Show abstractHide abstract

The effect of terephthalic acid (TPA) upon sulfadimethoxine contents in blood plasma was studied. The drug contents in blood plasma were increased by TPA feeding both in the rat and in the rabbit. The maximum contents of the drug in blood plasma were not so affected. However, 24 and 48 hr. after a single administration, they showed significant increases from that of the control. The drug excretion amounts in the urine of the TPA group was lower than those of the control and the plasma half-life of the drug was elongated by TPA administration, about 1.5 times in the rat and 1.9 times in the rabbit. Absorption of the drug through the gastrointestinal tract decreased with TPA administration and high contents of TPA might have a hindering effect on drug absorption from the small intestine. The contests of N⁴-acetate of the drug were increased by TPA administration. This increasing effect of TPA upon sulfadimethoxine seems to be concerned with excretion from the kidney. As a result, it is supposed that the plasma half-life of the drug is elongated.

View full abstract

Download PDF (809K)
Conformational Studies. I. Nuclear Magnetic Resonance Analysis on Conformation of 10β-and 10α-Oxy-enantio-deoxypodocarpic Acid Type Isomer.

Akira Tahara, Kenichi Hirao

1967 Volume 15 Issue 8 Pages 1145-1152
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1145

JOURNAL FREE ACCESS

Show abstractHide abstract

The configuration and conformation of 10β- and 10α-enantio-deoxypodocarpic acid type isomer and the corresponding lactone were discussed by their NMR spectrum analysis. The analysis was performed especially on the ABX type proton system as observed between 9-methylene protons and 10-proton.

View full abstract

Download PDF (811K)
The Structure of Serratenediol.

Yasuo Inubushi, Yoshisuke Tsuda, Takehiro Sano, Takeshi Konita, Sachik ...

1967 Volume 15 Issue 8 Pages 1153-1168
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1153

JOURNAL FREE ACCESS

Show abstractHide abstract

Retropinacol rearrangement of serratenediol established that either terminal ring of this triterpenoid has the partial structure (A). The accumulated chemical and spectroscopic evidences have been summarized in the structure and stereochemistry (1__=) containing sevenmembered ring for serratenediol, which was confirmed by further degradation into a tricyclic ketone (4__=7__=). The synthesis of this key product has now been achieved. The manner of acid isomerization of serratene derivatives has been also clarified. Serratenediol monoacetate, a minor triterpenoid constituent of Lycopodium serratum, was also established as (3__=), based on ORD examination of various ketonic derivatives.

View full abstract

Download PDF (1740K)
Gas Chromatographic Separation of Quinolizidine and Unsaturated Quinolizidines.

Masaaki Horiguchi

1967 Volume 15 Issue 8 Pages 1169-1171
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1169

JOURNAL FREE ACCESS

Show abstractHide abstract

Gas liquid chromatography was applied successfully to the separation of a mixture of five quinolizidine derivatives, the reduction products of quinolizinium bromide with sodium borohydride in water. Separation of a mixture of the reduction products and 1, 9α-dehydro-quinolizidine (IV) was reexamined using the same kinds of columns. Of these various liquid phases, DEGS was found the most effective for the complete separation in both the cases.

View full abstract

Download PDF (383K)
The C-Alkyl-aminomethylation of 3-Pyridazinol 1-Oxide Derivatives. I.

Genzo Okusa, Shozo Kamiya, Takanobu Itai

1967 Volume 15 Issue 8 Pages 1172-1177
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1172

JOURNAL FREE ACCESS

Show abstractHide abstract

The Mannich reaction of 3-pyridazinol 1-oxide using morpholine, piperidine, or dimethylamine gave the corresponding 6-alkylaminomethyl-3-pyridazinol 1-oxides which were also synthesized from 3-methoxy-6-chloromethylpyridazine.

View full abstract

Download PDF (645K)
Studies on Pyrimidine Derivatives and Related Compounds. XLVI. The Reactions of Diethyl Acetylphosphonate with Thiamine : Takamizawa Reaction (5).

Akira Takamizawa, Yoshio Hamashima, Yoshiro Sato, Hisao Sato

1967 Volume 15 Issue 8 Pages 1178-1182
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1178

JOURNAL FREE ACCESS

Show abstractHide abstract

3-(2-Hydroxy-and 2-acetoxy) ethyl-1, 4, 9-trimethyl-1, 6-dihydropyrimido [4', 5'-4, 5] pyrimido-[2, 3-c] [1, 4] thiazine (IIIb and IVb) were obtained by the reaction of thiamine (I) and diethyl acetylphosphonate (IIb). Alkaline hydrolysis of IIIb or IVb gave 2-methyl-4-(2-methyl-4-amino-5-pyrimidinyl)-methyl-5-methyl-6-(2-hydroxy) ethyl-2H-1, 4-thiazin-3 (4H)-one (Vb), which was decomposed to give VIIb by conc. HCl. The structures of IVb and VIIb were confirmed by the synthetic method.

View full abstract

Download PDF (671K)
Studies on Pyrimidine Derivatives and Related Compounds. XLVII. Reaction of Thiamine with Dialkyl Acylphos-phonates or Methyl Phenylacyl-phosphinates : Takamizawa Reaction 6

Akira Takamizawa, Yoshiro Sato, Hisao Sato

1967 Volume 15 Issue 8 Pages 1183-1187
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1183

JOURNAL FREE ACCESS

Show abstractHide abstract

Several kinds of dialkyl acylphosphonate (IIIa∼d, Va∼d) were synthesized and reacted with thiamine to give 1, 6-dihydropyrimido [4', 5'-4, 5] pyrimido [2, 3-c] [1, 4] thiazine derevatives (XIIA, B, XIIIA, B). Methyl phenylacylphosphinate also gave same result.

View full abstract

Download PDF (587K)
Studies on Antitumor Substances. V. Reaction of Thiosulfonates with Active Methylene Compounds.

Seigoro Hayashi, Mitsuru Furukawa, Junko Yamamoto, Kunihiro Niigata

1967 Volume 15 Issue 8 Pages 1188-1192
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1188

JOURNAL FREE ACCESS

Show abstractHide abstract

The reactions of benzyl benzene or p-toluenethiosulfonate with active methylene compounds were studied to elucidate the mechanism of anti-tumor activity of the analogous pentamethylene bismethanethiosulfonate with the expectation that any alkylation might occur. It was found that benzene or p-toluenethiosulfonate did not benzylate the active methylene compounds but one or two benzylthio groups were introduced. In the cases of less active methylene compounds, the reaction of thiosulfonates themselves occurred.

View full abstract

Download PDF (577K)
Reaction of N-Halosulfonamide. I. Reaction of N, N-Dihalobenzenesulfonamide with Cyclohexene. (1).

Yoshio Ueno, Shoji Takemura, Yoshiko Ando, Hiromi Terauchi

1967 Volume 15 Issue 8 Pages 1193-1197
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1193

JOURNAL FREE ACCESS

Show abstractHide abstract

Reaction between N, N-dihalobenzenesulfonamide (I) and cyclohexene (II) was studied. Addition products, DL-cis-and DL-trans-2-halo-1-benzenesulfonamidocyclohexanes (III and IV), and by-products, DL-trans-1, 2-dihalocyclohexane (V), 1, 3-cyclohexadiene (VI), 1-cyclohexen-3-one (VIII) and benzenesulfonamide (VII) were isolated and identified from the reaction mixture. A presumption on this reaction was also drawn.

View full abstract

Download PDF (661K)
Reaction of N-Halosulfonamide. II. Reaction of N, N-Dihalobenzenesulfonamide with Cyclohexene. (2).

Yoshio Ueno, Shoji Takemura, Yoshiko Ando, Hiromi Terauchi

1967 Volume 15 Issue 8 Pages 1198-1203
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1198

JOURNAL FREE ACCESS

Show abstractHide abstract

In order to examine the mode of reaction of N, N-dihalobenzenesulfonamide (I) with cyclohexene (II), the assumed intermediate, DL-trans-2, N-dibromo-1-benzenesulfonamidocy-clohexane (X), was synthesized and the formation of it in the pathway of the reaction of the bromo analog of I with II was proved. Comparing the behavior of N-bromo-N-methyl-benzenesulfonamide (XI) with that of X, the reaction of XI with II was examined, which afforded trans-1, 2-dibromocyclohexane (V), 1, 3-cyclohexadiene (VI), and 1-bromocyclohexene (XII). On the basis of these facts, the mechanism of the reaction of I with II was discussed.

View full abstract

Download PDF (608K)
Constituents of Convallaria. VII. Structure of Convallagenin-A.

Michiya Kimura, Masahiko Tohma, Itsuo Yoshizawa

1967 Volume 15 Issue 8 Pages 1204-1211
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1204

JOURNAL FREE ACCESS

Show abstractHide abstract

Convallagenin-A (I) was isolated from the flowers of Convallaria keisukei MIQ. and was shown to be a new 25L, 1, 3, 5-trihydroxyspirostane due to the conversion of it to &lrtri;^{1, 4}-tigogenone (XII). All of the hydroxyl groups in I were indicated to have β-configuration as a result of forming the 1, 5-carbonate (XIII), the 3, 5-carbonate (XIX), and the orthoester (XX). The chemical structure of convallagenin-A (I) was thus elucidated as 25L, 5β-spirostan-1β, 3β, 5β-triol.

View full abstract

Download PDF (892K)
Synthesis of 3-Sarcosine-, 3-Glycine-, and 3-L-Alanine-6-Glycine-Bradykinin and 3-Glycine-Bradykinin.

Kenji Suzuki, Takashi Abiko

1967 Volume 15 Issue 8 Pages 1212-1218
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1212

JOURNAL FREE ACCESS

Show abstractHide abstract

The three analogs of bradykinin are described in which L-proline residue in 3-position of 6-glycine-bradykinin is substituted for sarcosine, glycine, and L-alanine residue respectively. 3-Glycine-bradykinin and its O-acetyl compound are also described. The biological activity of the five analogs is compared with that of bradykinin on an isolated guinea pig ileum.

View full abstract

Download PDF (1042K)
Structure-Activity Relationship of Colistins.

Kunihiro Nakajima

1967 Volume 15 Issue 8 Pages 1219-1224
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1219

JOURNAL FREE ACCESS

Show abstractHide abstract

1) Purified samples of polymyxin group antibiotics were shown to be remarkable antimicrobial agents as colistin against E. coli. 2) Removal of the C₉-fatty acid from the colistin molecule resulted in the decrease of the activity. 3) The side chain moiety itself showed no antimicrobial activity. 4) The cyclic peptide moiety showed an antimicrobial activity although it was less active than the parent antibiotic. These results indicate that the "active"structure responsible for the antimicrobial activity is the"cyclic peptide moiety"in colistin molecule.

View full abstract

Download PDF (624K)
Studies on Hydrogen Exchange. VI. The Base-catalyzed Hydrogen Exchange of α-Hydrogens in Alkyl Groups substituted on Some Nitrogen-containing Heteroaromatic Rings.

Yutaka Kawazoe, Masako Ohnishi, Yuko Yoshioka

1967 Volume 15 Issue 8 Pages 1225-1231
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1225

JOURNAL FREE ACCESS

Show abstractHide abstract

Hydrogen-deuterium exchange of α-hydrogens of the side-chain alkyl groups substituted in pyridine, quinoline, isoquinoline, their N-oxides and N-alkyl halides were carried out by heating their D₂O solutions containing sodium hydroxide or sodium carbonate. Exchange reactivities of these hydrogens were discussed in term of the electronic effect of the nitrogen function in these heteroaromatic rings.

View full abstract

Download PDF (661K)
Syntheses of Estriol Monoglucuronides.

Toshio Nambara, Kazuhiro Imai

1967 Volume 15 Issue 8 Pages 1232-1238
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1232

JOURNAL FREE ACCESS

Show abstractHide abstract

Syntheses of estriol glucosiduronic acids were carried out employing Koenigs-Knorr reaction. Of these three 16- and 17-glucuronides were prepared from estrone 3-benzyl ether, and 3-isomer from estriol 16, 17-diacetate as shown in Chart 1. All the glucuronides thus obtained underwent hydrolysis with beef liver β-glucuronidase to furnish estriol and glucuronic acid.

View full abstract

Download PDF (896K)
Fundamental Studies on Clinical Chemistry. XII. On Some Aspects in the Colorimetries of Steroidal Compounds using p-Nitrophenylhydrazine. (1). Hydrazones derived from &lrtri;⁵-3-Hydroxysteroids.

Michiya Kimura, Toshihiro Nishina

1967 Volume 15 Issue 8 Pages 1239-1242
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1239

JOURNAL FREE ACCESS

Download PDF (563K)
Fundamental Studies on Clinical Chemistry. XIII. On Some Aspects in the Colorimetries of Steroidal Compounds using p-Nitrophenylhydrazine. (2). Decomposition of p-Nitrophenylhydrazine in Alkaline Dimethylformamide Solution.

Michiya Kimura, Toshihiro Nishina

1967 Volume 15 Issue 8 Pages 1242-1246
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1242

JOURNAL FREE ACCESS

Download PDF (565K)
Studies on Morphine-like Compounds. VI. Transformation of Thebaine to Benzomorphan Analogues by Ozonolysis.

Tadashi Sasaki, Ken Kanematsu

1967 Volume 15 Issue 8 Pages 1247-1250
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1247

JOURNAL FREE ACCESS

Download PDF (513K)
On the Iridoid Constituent isolated from the Roots of Scrophularia buergeriana MIQ.

Isao Kitagawa, Tadashi Nishimura, Masazumi Takei, Itiro Yosioka

1967 Volume 15 Issue 8 Pages 1254-1256
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1254

JOURNAL FREE ACCESS

Download PDF (471K)
Isolation of a Plant Growth Inhibitory Substance from Garden Peas (Pisum sativum L.) and Its Identification with (+)-Abscisin-II

Yo Isogai, Toshihiko Okamoto, Yasuo Komoda

1967 Volume 15 Issue 8 Pages 1256-1257
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1256

JOURNAL FREE ACCESS

Download PDF (390K)
A Convenient Nucleotide Synthesis by the Fusion Method

Hiroaki Nomura, Ikuo Suhara, Norihiro Uno

1967 Volume 15 Issue 8 Pages 1258-1260
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1258

JOURNAL FREE ACCESS

Download PDF (450K)
Synthesis of Purine Cyclonucleoside having 8, 3'-O-Anhydro Linkage

Morio Ikehara, Masakatsu Kaneko

1967 Volume 15 Issue 8 Pages 1261-1262
Published: August 25, 1967
Released on J-STAGE: March 31, 2008

DOIhttps://doi.org/10.1248/cpb.15.1261

JOURNAL FREE ACCESS

Download PDF (343K)

Register with J-STAGE for free!