Reactivities of 4-Chloropyridine Derivatives and Their 1-Oxides.

Abstract

Rates of reaction of 4-chloropyridine (I), 4-chloro-2-picoline (II), 4-chloro-3-picoline (III), 4-chloro-2, 6-lutidine (IV), 3-nitro-4-chloro-2, 6-lutidine (V), 2-trichloromethyl-3-nitro-4-chloro-6-methylpyridine (VI) and their 1-Oxides with sodium methoxide in methanol have been measured, and rate coefficients, activation energies and entropies of activation were calculated. The order of the reaction rate at 0°found from our experiments was as follows ; VI>V-Oxide>V>I-Oxide>II-Oxide>III-Oxide>IV-Oxide>I>II>III>IV.