Abstract
The relationship between the duration of pentobarbital induced sleep and respiratory oxygen tension was investigated in mice and cats. Pentobarbital, when administered to cats in a high dose (70 mg/kg), resulted in irregular respiration, and prolonged biologic half life. And found that the characteristic curve of disappearance of pentobarbital obtained from a high dose administration of pentobarbital were caused by low activity of liver microsomal oxidative enzyme and not by the tissue accumulation. The low activity was assumed to be caused by insufficiency of oxygen required by oxidative enzymes.
