Abstract
2-Morpholino-, 2-piperidino-3-(2-methyl-4-aminopyrimidin-5-yl) methyl-3a-methylperhydrofuro [2, 3-d] thiazole (VI, IX), and N, N'-bis {2-[3-(2-methyl-4-aminopyrimidin-5-yl) methyl-3a-methylperhydrofuro [2, 3-d] thiazolyl} piperazine (X) were synthesized by the reaction of B1 hydrochloride (I) or B1-Na (II) with corresponding amines. Reactions of II with aniline and benzylamine were also undertaken to result in giving N-[1-methyl-2-phenylimino (or 2-oxo-)-4-hydroxybutyl]-N-[(2-methyl-4-aminopyrimidin-5-yl) methyl]-formamide (XIV, XVII). Brief reaction mechanisms are discussed.
