Direct bromination of adenine nucleotides was achieved by the use of bromine-water as brominating agent in the alkaline or buffer solution. By this method 8-bromoadenosine 2-', 3'-and 5'-monophosphate, 5'-di- and tri-phosphate, and 3', 5'-cyclic phosphate were synthesized in satisfactory yield. Mechanism of bromination of adenine nucleotides was discussed.
