Investigations on Pantothenic Acid and Its Related Compounds. XIX. Chemical Studies. (9). Syntheses of 2'-Ketopantothenic Acid and 2', 2''-Diketopantethine

Abstract

Wieland synthesized 2'-ketopantothenic acid [N-(4-hydroxy-3, 3-dimethyl-2-oxobutyryl)-β-alanine] (Keto-PaA) (V) and reported its uneffectiveness as the growth factor for Streptobacterium plantarum 10 S (=Lactobacillus arabinosus). The keto compound (VI) corresponding to pantethine, 2', 2''-diketopantethine (Keto-PTSS), has not yet been known. It seems very interesting to examine the possibility of enzymatic conversion of these compounds to the corresponding active vitamins in mammalian body. This paper describes the synthesis of these keto compounds.