Adsorption of Solute from the Solutions. II. Competitive Adsorption of Cyanocobalamin with Pyridoxine and Thiamine on Talc

Abstract

In the production of tablets containing cyanocobalamin, it has been advised to use magnesium stearate as a lubricant because talc adsorbs cyanocobalamin and consequently interferes with intestinal absorption and assay of the vitamin. But magnesium stearate can not always replace talc because of the difference of the lubrication mechanisms. Cyanocobalamin is usually formulated together with other vitamins, especially pyridoxine and thiamine, in the tablets. In this work the adsorption of cyanocobalamin on talc in the presence of pyridoxine and thiamine was studied to obtain some information about employment of talc as a lubricant of such tablets, and the competitive adsorption was treated some what theoretically.