A Nuclear Magnetic Resonance Spectral Study of 5α, 13α-Androstanes

Abstract

The chemical shifts of angular methyl protons of 5α, 13α-androstane derivatives were measured in deuteriochloroform and the effects of various substituents in ring D on shift values were estimated. The pyridine-induced solvent shifts in 18-proton signal were recognized with the 16- and 17-hydroxylic compounds. Correlation of the coupling constant (JH_{15, 16}) and conformation of ring D has also been discussed.