抄録
Metabolites of guaiacol glycerol ether and its mononicotinate in rabbit urine were investigated. As the metabolites of guaiacol glycerol ether, β-(2-methoxyphenoxy) lactic acid, (2-methoxyphenoxy) acetic acid, β-(4-hydroxy-2-methoxyphenoxy) lactic acid, and (4-hydroxy-2-methoxyphenoxy) acetic acid (trace) were separated with unchanged GGE, and identified with the authentic samples by thin-layer chromatography. Two of the metabolites, β-(4-hydroxy-2-methoxyphenoxy) lactic acid and (4-hydroxy-2-methoxyphenoxy) acetic acid showed hypocholesteremic action on hypercholesteremia caused by intravenous injection of Triton to rats. As metabolites of guaiacol glycerol ether in rabbit liver and kidney in vitro, only β-(2-methoxyphenoxy) lactic acid was detected with the unchanged drug by thin-layer chromatography.
