Absorption and Excretion of Drugs. XLI. Studies on the Gastrointestinal Absorption of 2-Pyridine Aldoxime Methiodide and Its Derivatives.

Abstract

The gastrointestinal absorption of pyridine aldoxime methiodides has been studied in rats using single loop and perfusion techniques. Contrary to their apparent physicochemical properties, these compounds were absorbed from the intestine to an appreciable extent but not from the stomach and the rectum within one hour. The absorption from the intestine became saturated when the concentration of the drugs increased and one will inhibit the absorption of the other. The presence of a metabolic inhibitor in the drug solution had no effect on the absorption of these compounds. Despite the complexity of the systems used, a straight line relationship between the reciprocal of absorption rate and the reciprocal of initial concentration was obtained for each compound studied.