Abstract
The critical distance, R0, which is the rate parameter for the transfer of excitation energy by resonance between aromatic amino acids and 14 kinds of non-steroidal anti-inflammatory drugs or some of other aromatic compounds was calculated. The rank correlation between the R0 values and anti-inflammatory activity were found to be significant, and the activity of various nonsteroidal anti-inflammatory drugs were illustrated uniformly at a molecular level. Finally, a possibility of formation of electronic excited state of aromatic amino acid residues in living cell was discussed.
