Abstract
The reaction of ethyl 2- (3-chloro-2-quinoxalinyl) -2-cyanoacetate (I) with various amines : ammonia, methylamine, ethanolamine, γ-dimethylaminopropylamine, benzylamine, and p-phenetidine, gave the corresponding 1-substituted ethyl 2-aminopyrrolo [2, 3-b] quinoxaline-3-carboxylates (IIIa-f) at about 80-90% yield. The similar reaction of α- (3-chloro-2-quinoxalinyl) -malondinitrile (II) with various primary amines was carried out to give the corresponding 1-substituted 2-aminopyrrolo [2, 3-b] quinoxaline-3-carbonitriles (VIIa-d) at 86-94% yield (Table I).
