Abstract
Two coenzyme A analogs having purine base different from adenine, such as inosino-(IV) and guano-coenzyme A (IX), have been synthesized by application of the method via the thiazoline intermediate in the same manner as the total synthesis of coenzyme A. Inosino-coenzyme A has been also obtained by deamination with nitrite from the disulfide from of coenzyme A. Synthesis of guano-coenzyme A has been more efficiently effected by a combination of the methods of Moffatt and Khorana, for the formation of pyrophosphate, and of Michelson, for 2', 3'-cyclic phosphate fission, than the thiazoline method.
