Abstract
Four new compounds, spinulosin-hydrate (VI), spinulosin quinol-hydrate (II), dihydrospinulosin quinol (VII), and fumigatin chlorohydrin (VIII) were isolated from the culture medium of Aspergillus fumigatus DH 413 and Fersenius 4399 by ion exchange chromatography, and their chemical structures were determined. From the tracer experiments using 14C-labeled compounds, the metabolic relationships among metabolites were proposed as shown in Chart 4. The key different point between spinulosin producing and unproducing strains in Aspergillus fumigatus were also discussed.
