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Volume 18, Issue 3
Displaying 1-35 of 35 articles from this issue
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KOTARO TAKAHASHI, YOSHIHIDE HAYASHI, MASAKO TAKANI1970 Volume 18 Issue 3 Pages 421-428
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS1) Dihydropaulownin (VI) C20H20O7, mp 125°, dihydropaulownin acetate (VII) C22H22O8, mp 105-106°, dihydrosesamin (II) C20H20O6, mp 98-99° and dihydrosesamin acetate (III) C22H22O7, mp 91-93° were prepared. 2) The NMR spectra of II, III, VI and VII were studied. 3) The Mass spectra of VIII and XI were studied. 4) The structure of isopaulownin was revised as X.View full abstractDownload PDF (700K) -
KIYOSHI TAKIURA, HIDETAKA YUKI, SUSUMU HONDA, YASUO KOJIMA, LANYU CHEN1970 Volume 18 Issue 3 Pages 429-435
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSSulfation of D-glucose, D-galactose, D-mannose and D-fructose with concentrated sulfuric acid yielded pure trisulfates of these hexoses. The situation of the sulfate groups in these trisulfates was decided on the basis of the behavior to oxidizing agents, methylation analyses and periodate oxidation. 1, 3, 6-Substitution for the aldohexoses and 1, 2, 4-substitution for the ketohexose were established.View full abstractDownload PDF (745K) -
AKIRA AKAHORI, MASATOSHI TOGAMI, TORU IWAO1970 Volume 18 Issue 3 Pages 436-439
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe second-year plants of Dioscorea tokoro MAKINO were maintained under short-day (8 hr light and 16 hr dark) or long-day conditions (16 hr light and 8 hr dark) for a month. The amount of yonogenin and tokorogenin of the aerial parts was markedly increased together with an increase in the weight of these parts by elongating the photoperiod, while the concentration of isodiotigenin was decreased by this treatment. Light conditions did not effect on the underground parts of the plant.View full abstractDownload PDF (561K) -
KEN IKEDA, KENJI MIYATA, TAKASHI IWATA, FUMIKO KAWATA, KYOKO KUROME1970 Volume 18 Issue 3 Pages 440-448
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFor the elucidation on the mechanism of change of methanesulfonated drug in vivo, the rate of hydrolysis was investigated on the derivatives of substituted anilines. In aqueous solution the hydrolysis was found to be reversible between pH 4 and 8 and the rate is pH-independent. The pH-profile of the reverse reaction rate indicated that the formation of methanesulfonic acid derivative occures between molecular aniline and hydroxymethanesulfonate. The electron donating groups facilitate the hydrolysis as well as reverse reaction and the electron attracting groups on the contrarily retard both reactions. Methylation on amino group or C atom of methylene group promotes the hydrolysis significantly. To see the change in rabbit, Na p-phenetidinomethanesulfonate was intravenously administrated and the plasma concentration of intact phenetidine was followed. The curves had maxima which appear within ten minutes. The early maximum would be explained by rapid transference of phenetidine into extravascular fluid or organs. Pharmacokinetic inquiries were given on the processes of the change in blood refering to the data obtained by supplemental studies.View full abstractDownload PDF (876K) -
IKUO MORIGUCHI, SHIZUO FUSHIMI, NOBUYOSHI KANENIWA1970 Volume 18 Issue 3 Pages 449-452
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe adsorption of 14 monosubstituted benzoic acids, together with 1-naphthoic acid and cyclohexanecarboxylic acid, on graphite from aqueous solutions at 5° was investigated. The adsorption isotherms apparently fitted the Langmuir equation. The logarithmic value of the first equilibrium constant per unit weight of graphite was significantly correlated with plane size of adsorbate molecule, and not with its pKa and π, the Hansch-Fujita substituent constant. Furthermore, decreasing order of the affinity to graphite was as follows : 1-naphthoic acid>benzoic acid>cyclohexanecarboxylic acid. These results may indicate that adsorbed acids are mostly oriented flat on graphite surface, and plane-to-plane stacking between acid molecule and fused benzene ring plane of graphite seems to be dominant among possible adsorption forces.View full abstractDownload PDF (460K) -
TOSHIO NAMBARA, KAZUTAKE SHIMADA, SHUJIRO GOYA1970 Volume 18 Issue 3 Pages 453-457
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSIn order to clarify the structure-activity relationship of the cardiotonic steroids the synthesis of the 14, 15-epoxyisobufadienolides, in which C-17 is linked to 6-position of the α-pyrone ring, has been undertaken. When refluxed with triphenyltin hydride in xylene, pregna-14, 16-dien-20-ones underwent selective hydrogenation to yield the corresponding ⊿14-unsaturated compounds. Condensation with ethyl orthoformate followed by cyclization with malonic acid gave the ⊿14-isobufadienolides. Subsequent treatment with N-bromoacetamide and then with alumina resulted in formation of the desired 14β, 15β-epoxyisobufadienolides (VIIIa, b). The epimeric 14α, 15α-epoxides (VIa, b) were also prepared with the object of comparing the biological activity.View full abstractDownload PDF (661K) -
KEIICHI NITTA, YUZURU YAMAMOTO, YOSHISUKE TSUDA1970 Volume 18 Issue 3 Pages 458-464
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA new metabolic product of Oospora astringenes, oospolide, was isolated by ionexchange chromatography of the culture medium, and the structure was determined as the formula (I). The biosynthesis of oospolide was also studied by using 14C-acetates, and head-to-tail condensation of acetate units was presumed as the biosynthetic mechanism.View full abstractDownload PDF (825K) -
HARUO SAIKACHI, HARU OGAWA, YAYOI MINAMI, KATUTOSHI SATO1970 Volume 18 Issue 3 Pages 465-473
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAttempts to obtain an unsaturated macrocycle (3) using the Wittig reaction of furan-2, 5-bis (methylenetriphenyl phosphonium chloride) (1) with 2, 5-furan-bis (2-cis-4-trans-2, 4-dimethyl-2, 4-pentadienal) (2) were unsuccessful by the occurence of undesired 1, 6-elimination of triphenylphosphine from bisphosphonium salt (1). In an alternative reaction of 2, 5-furandialdehyde with furan-2, 5-bis (2-cis-4-trans-2, 4-dimethyl-2, 4-pentadienyl triphenyl phosphonium bromide) gave major formation of uncyclized polyendial isomers, and no unsaturated macrocycle (3) was isolated. Three isomers of polyendials of 17, 18 and 19 were purely isolated and assigned their structures.View full abstractDownload PDF (1007K) -
TOSHIO NAMBARA, SEIJIRO HONMA, SETSUKO AKIYAMA1970 Volume 18 Issue 3 Pages 474-480
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe new synthetic routes leading to the 2-methoxyestrogens from the readily available compounds have been investigated. Utilization of both Friedel-Crafts and Baeyer-Villiger reactions with estrone and estradiol 3-methyl ethers gave the desired 2-methoxyestrogens in overall yield of ca. 50%. Fries rearrangement with estrone acetate and Friedel-Crafts reaction with 2-methoxy-3-deoxyestrogens were also undertaken. The chemical shifts of the aromatic protons of the 2, 3-substituted estratrienes are collected in Table I and II.View full abstractDownload PDF (774K) -
SADAO AOYAMA, KANZO SASAKI1970 Volume 18 Issue 3 Pages 481-489
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESS3β, 20β-Diacetoxy-8, 9-seco-5α-pregnane-8, 9, 11-trione (4) has been prepared from 3β, 20β-diacetoxy-5α-pregnan-12-one (1) via keto-glycol (3). Alumina catalyzed condensation of trione (4) furnished 3β, 20β-diacetoxy-11β-hydroxy-9 (8→7), 8 (9→11)-diabeo-5α, 7ξ, 14α-pregnane-8, 9-dione (5), the structure of which was determined by chemical and physical means. The plausible stereochemistry of the compound has been proposed mainly on the basis of chemical behaviors.View full abstractDownload PDF (957K) -
ATSUSUKE TERADA, YUKICHI KISHIDA1970 Volume 18 Issue 3 Pages 490-496
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDimethylsulfonium 2-oxo-3, 4-diphenyl-cis-3-butenylide derivatives (IVa-e) were prepared from dimethyl 3-phenyl-2-propynylsulfonium bromide (III) and benzaldehyde derivatives and its addition mechanism were considered.View full abstractDownload PDF (656K) -
ATSUSUKE TERADA, YUKICHI KISHIDA1970 Volume 18 Issue 3 Pages 497-504
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTreatment of dimethyl 2-butynylsulfonium bromide (II) with benzaldehyde gave cis-and trans-2, 4-diphenyl-5-methyl-6-(2-phenyl-trans-1, 2-epoxyethyl)-1, 3-dioxin (III and IV), 1, 5-diphenyl-2-methyl-trans-4, 5-epoxy-trans-1-penten-3-one (V) and methyl 2-methyl-5-hydroxy-5-phenyl-2, 3-pentadienyl sulfide (VI). Dimethyl 2-propynylsulfonium bromide (VIII), however, reacted with benzaldehyde to give only one product, 1, 5-diphenyltrans-4, 5-epoxy-trans-1-penten-3-one (IX). A mechanistic assumption for the formation of these compounds from the acetylenic sulfonium bromides was given.View full abstractDownload PDF (782K) -
ATSUSUKE TERADA, YUKICHI KISHIDA1970 Volume 18 Issue 3 Pages 505-510
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDimethylsulfonium 2-oxo-3, 4-diphenyl-3-butenylide derivatives (Ia-c) rearranged in boiling ethanol, in a Pummerer-type fashion, to produce 1, 2-diphenyl-3-methylthiomethoxy-1, 3-butadiene (IVa-c). Nucleophilicity of the ylid (I) was examined by the reactions described below. I-a still reacted with dimethyl acetylenedicarboxylate and ethyl propiolate to afford new stable ylids of dimethylsulfonium 1, 2-dimethoxycarbonyl-4-oxo-5, 6-diphenyl-1, 5-hexadien-3-ylide (IX) and dimethylsulfonium 1-ethoxycarbonyl-4-oxo-5, 6-diphenyl-1, 5-hexadien-3-ylide (X), respectively. I also reacted with phenylisocyanate derivatives forming stable ylids, dimethylsulfonium 1-phenylcarbamoyl-2-oxo-3, 4-diphenyl-3-butenylide derivatives (XIa-e).View full abstractDownload PDF (602K) -
SEIJI MIYANO, NOBUHIRO ABE, AKIKO ABE1970 Volume 18 Issue 3 Pages 511-514
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA new synthesis of N-(2-pyridylmethylene) aniline (I) is described. The method consists of heating a mixture of 2-pyridinemethanol, aniline, and nitrobenzene in the presence of potassium hydroxide. Extension of the reaction to some related compounds was made. By-products accompanied with ortho-substituted derivatives of I were characterized as pyridylmethylene-bis-amines.View full abstractDownload PDF (534K) -
ISAO SUGIMOTO1970 Volume 18 Issue 3 Pages 515-526
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAbsorption rates of carbazochrome and nicotinamide in the presence of each complexing agent (caffeine and hydroxyethyltheophylline, respectively) were determined in order to make sure that the increase or decrease of absorption rate in the presence of the complexing agent was due to the intra-luminal complex formation. The rate was determined by pretreatment, tied loop, and everted methods. In addition, the effect of buffer composition and the addition of the third additive to the complexing system were studied. These results suggest that the effect of complexing agent on the absorption rate of drug is apparently due to complex formation. To demonstrate the specificity of the small intestine by comparing with the rat stomach, carbazochrome-caffeine complexing system was examined on the absorption rate from the stomach. It was found that the small intestine did not behave specifically to the absorption of carbazochrome in the presence of caffeine. A theoretical equation was derived to obtain the stability constant at the surface of the absorption rate-limiting barrier. The constant did not differ appreciably from that determined in the bulk solution. A good fit of the absorption rate to the theoretical model suggested that the stability constant at the surface of the absorption rate-limiting barrier was similar to that in the bulk solution.View full abstractDownload PDF (1162K) -
YOSHIKAZU OKA, SHOJI KISHIMOTO, HIROSHI HIRANO1970 Volume 18 Issue 3 Pages 527-533
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSA novel cleavage reaction of thiamin to give 4-amino-2, 5-dimethylpyrimidine (III) and 2-benzoyl-5-(2-hydroxyethyl)-4-methylthiazole (IV) has been discovered. The reaction involves the treatment of thiamin chloride hydrochloride (I) with two mole equivalents of triethylamine and an excess of benzaldehyde in methanol. The finding was further extended to the reactions of thiamin and its homologs with a variety of aromatic aldehydes to give several new 2-acylthiazoles. The pyrimidine moiety of thiamin was indispensable for these reactions. On the other hand, the reaction of thiamin with cinnamaldehyde gave 2, 9a-dimethyl-9-(2-hydroxyethyl)-7-(3-methoxy-3-phenylpropionyl)-5, 9, 9a, -10-tetrahydro-7H-pyrimido [4, 5-d] thiazolo [3, 4-a] pyrimidine (XV).View full abstractDownload PDF (703K) -
YOSHIKAZU OKA, SHOJI KISHIMOTO, HIROSHI HIRANO1970 Volume 18 Issue 3 Pages 534-541
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe structure of a product which is obtained by the reaction of thiamin with benzaldehyde was established as 2-[α-(4-amino-2-methyl-5-pyrimidinylmethyl)-α-hydroxybenzyl]-5-(2-hydroxyethyl)-4-methylthiazole (III). The mechanism of the reaction is discussed and the syntheses of several homologs of III as well as their chemical reactions are described.View full abstractDownload PDF (725K) -
MUNEMITSU TOMOEDA, RUMIKO KIKUCHI, MUTSUKO URATA, TSUYOSHI FUTAMURA1970 Volume 18 Issue 3 Pages 542-549
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSThe Diels-Alder reaction of diethyl azodicarboxylate (I) with steroid 2, 4-and 5, 7-dienes and its stereochemistry were reported. The azo-ester (I) reacted with cholesta-2, 4-diene (II) to afford three one-to-one adducts, i.e. the 1, 4-adduct (IV) at 2α and 5α positions and two addition-abstraction adducts (V and VI) isomeric at 3 position, and diethyl hydrazinedicarboxylate (VII) in 21.4%, 10.8%, 5.2%, and 12.2% yields respectively. The 1, 4-adduct (IV) was chemically modified to its dihydro derivatives, VIII and IX. The reaction of the azo-ester (I) with 3β-benzoyloxycholesta-5, 7-diene (III), on the other hand, led to the formation of two one-to-one adducts, i.e. the 1, 4-adduct (XI) at 5α and 8αpositions and an addition-abstraction adduct (XII) at 7α position in 4.2% and 36% yields respectively. The 1, 4-adduct (XI) was converted to its dihydro derivative (XIII). The result showed that whereas with the 2, 4-diene (II) as substrate, the 1, 4-addition and addition-abstraction reactions take place to the almost same extent, with the 5, 7-diene (III) as substrate the latter reaction is preferred. Stereochemical aspects of the different reactivity of the azo-ester (I) toward those dienes were discussed.View full abstractDownload PDF (979K) -
SEIJI MIYANO, NOBUHIRO ABE1970 Volume 18 Issue 3 Pages 550-553
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAmong the aryl-aliphatic nitriles subject to alkylation, phenylacetonitrile is especially reactive and its methylene hydrogens are readily replaced by one or two alkyl groups. The benzylation of this substance is most commonly performed with benzyl chloride in the presence of finely powdered sodium amide in an inert solvent. The preliminary communication from this laboratory reported several examples of benzylation of phenylacetonitrile and related nitriles (I) by means of benzyl alcohol and sodium. (Chart 1). The present paper is concerned with the detailed study of the reaction and additional comments about the mechanism.View full abstractDownload PDF (475K) -
YOSHIYASU FURUKAWA, YOSHIO YOSHIOKA, KINICHI IMAI, MIKIO HONJO1970 Volume 18 Issue 3 Pages 554-560
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSTreatment of 2, 2'-anhydro-1-(3, 5-di-O-acetyl-β-D-arabinofuranosyl) uracil (II) with sodium ethanethiol afforded 1-(3-ethylthio-3-deoxy-β-D-xylofuranosyl) uracil (IV) in 90% yield. Hydrogenation of 2, 2'-anhydro-1-(5-O-benzoyl-3-O-mesyl-β-D-arabinofuranosyl)-uracil (III) with Raney nickel resulted in formation of the 5, 6-dihydro derivative (VI). 5'-O-Benzoyl-2'-bromo-2'-deoxy-3'-O-mesyluridine (VII) was hydrogenated in the presence of Pd·BaSO4 or Raney nickel to yield 5'-O-benzoyl-2', 3'-dideoxyruidine (VIII). VIII was treated with alkali to give 2', 3'-dideoxyuridine (IX) in 50% overall yield from uridine. The mechanism of the reductive elimination of the cis-bromohydrin mesylate (VII) was presented. The treatment of VII with sodium methoxide in methanol gave 1-(2-bromo-2, 3-dideoxy-2-ene-β-D-glyceropentofuranosyl) uracil (XII) which was converted to IX by the catalytic hydrogenation. Bromination of IX afforded 5-bromo-2', 3'-dideoxyuridine (XIV).View full abstractDownload PDF (783K) -
YUZURU YAMAMOTO, MIKIKO SHINYA, YASUHARU OOHATA1970 Volume 18 Issue 3 Pages 561-569
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFour new compounds, spinulosin-hydrate (VI), spinulosin quinol-hydrate (II), dihydrospinulosin quinol (VII), and fumigatin chlorohydrin (VIII) were isolated from the culture medium of Aspergillus fumigatus DH 413 and Fersenius 4399 by ion exchange chromatography, and their chemical structures were determined. From the tracer experiments using 14C-labeled compounds, the metabolic relationships among metabolites were proposed as shown in Chart 4. The key different point between spinulosin producing and unproducing strains in Aspergillus fumigatus were also discussed.View full abstractDownload PDF (932K) -
BUNJI SHIMIZU, MICHIKO MIYAKI1970 Volume 18 Issue 3 Pages 570-580
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSBenzyl, allyl and 3-methyl-2-butenyl groups were found to migrate from N-3 to N-9 or N-7 position of the N6-acyladenines. On heating in the presence of hydrogen halide, 3-benzyl-N6-acyladenines underwent intermolecular benzyl migration giving rise to 9-benzyl derivatives and a small amounts of the 7-benzyl isomers. 3-Methyl-2-butenyl group in N6-acyltriacanthine migrated under similar conditions to afford the 9-(3-methyl-2-butenyl) derivatives, whereas mercuric halide or cyanide caused intramolecular rearrangement to give the 9-(1, 1-dimethyl-2-propenyl) isomers.View full abstractDownload PDF (1142K) -
JUNICHI NAKAZAWA, YUKIO SUGIMURA, NOBUO SOMA1970 Volume 18 Issue 3 Pages 581-586
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSRearrangement of amino group on the seven-membered ring of cycloheptoxazole derivatives was examined. Dimethylamino group in 6-dimethylamino-2-phenyl-6H-cycloheptoxazole (Ia) underwent rearrangement to C-4 and C-8 on standing in a solution, and the ratio of three isomers, Ia, 4-dimethylamino-2-phenyl-4H-cycloheptoxazole (IIa), and 8-dimethylamino-2-phenyl-8H-cycloheptoxazole (IIIa), reached an equilibrium at about 3 : 5 : 2. By the incorporation of dimethylamino-15N into Ia and interchange between the amino group in 6-dimethylamino-2-(2-naphthyl)-6H-cycloheptoxazole (IX), the rearrangement was presumed to take place intermolecularly. 2-(p-Tolyl)-(Ib) and 2-(p-nitrophenyl)-6-dimethylamino-6H-cycloheptoxazole (Ic) also showed similar rearrangement of the dimethylamino group, while the rearrangement was not observed in 2-phenyl-6-(p-toluidino)-6H-cycloheptoxazole (VI) and 5-dimethylamino-5H-benzocycloheptene (VIII).View full abstractDownload PDF (703K) -
YUICHI KANAOKA, TATSUO HAMADA, OSAMU YONEMITSU1970 Volume 18 Issue 3 Pages 587-590
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSPolyphosphate ester (PPE) was demonstrated to be a good agent in the benzazole synthesis. Benzoxazoles and benzthiazoles were prepared from o-substituted anilines and free carboxylic acids under mild conditions. Mechanisms for this reaction were briefly discussed.View full abstractDownload PDF (478K) -
YOSHIHISA KUDO, TAKASHI OHSHIMA, SHIZUKO SATO, KAZUO WATANABE, HIDEOMI ...1970 Volume 18 Issue 3 Pages 591-595
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSAs a part of the research on the mechanisms of action of the centrally acting muscle relaxants, the tentative correlation between the effect on the polysynaptic reflex and gamma-aminobutyric acid (GABA) level in the spinal cord was studied in young chicks. The spinal GABA concentration of chicks was found to be 12.1 mg/100 g wet tissue. The spinal GABA level was not significantly altered by several relaxants and stimulants. It was found that amino-oxyacetic acid (AOAA), an inhibitor of GABA transaminase, markedly increased the spinal GABA level in chicks. The inhibitory effect of mephenesin or exogenous GABA on the crossed extensor reflex in AOAA-pretreated chicks was not significantly different from that in AOAA-untreated ones. Consequently, evidence for the direct correlation between the action of the centrally acting muscle relaxant and the GABA level in the spinal cord could not be obtained.View full abstractDownload PDF (636K) -
YUKIO AKAHORI, SEIZI KATAYAMA, TADATAKA NORO, SEIGO FUKUSHIMA, YASUHIS ...1970 Volume 18 Issue 3 Pages 596-601
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSWith the analysis of the nuclear magnetic resonance spectra of protofarrerol (IA) and triacetylfarrerol (IIC), the chemical shifts and the coupling constants containing the relative sign are determined using the double resonance techniques, the spin-decoupling and the spin-tickling. Especially the ABX spin systems in these compounds give the similar conformation and the same relative sign of coupling constants, even if the substituent of C-2 position is a phenyl or a alicyclic ring. The computations for the spin systems are carried out with the simulations and the iterations.View full abstractDownload PDF (583K) -
MANKI KOMATSU, TSUYOSHI TOMIMORI, KATSUO HATAYAMA, YUKIKO MAKIGUCHI, N ...1970 Volume 18 Issue 3 Pages 602-607
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSFrom the root of Sophora subprostrata CHUN et T. CHEN two new flavonoids, named sophoradin and sophoranone, have been isolated, whose structures have been established to be I and IX, respectively, by the spectral properties of them and their derivatives and by chemical data.View full abstractDownload PDF (676K) -
TAICHIRO KOMENO, HIKARU ITANI1970 Volume 18 Issue 3 Pages 608-616
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSCholest-4-en-2β, 3β-episulfide and the epimers of cholest-5-en-2, 3-episulfide were synthesized upon treatment of the corresponding thiocyanatohydrin acetate with alkali. However, synthesis of cholest-4-en-2α, 3α-episulfide in a similar way failed. This could be achieved successfully but in low yield by treatment of 3β-acetoxycholest-4-en-2α-ethyl xanthate with alkali. CD and ORD curves of these episulfides were studied.View full abstractDownload PDF (1097K) -
TOSHIO NAMBARA, KAZUTAKE SHIMADA, SHUJIRO GOYA, NOBUO SAKAMOTO1970 Volume 18 Issue 3 Pages 617-619
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (434K) -
SUSUMU KAWASHIMA, MUNEMITSU TOMOEDA1970 Volume 18 Issue 3 Pages 620-625
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (652K) -
TOSHIO NAMBARA, YASUHIKO MATSUKI, TOSHIHIRO KUDO, TAKEHIKO IWATA1970 Volume 18 Issue 3 Pages 626-628
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (450K) -
YUKIO SAITO, YOSHIKO KANEMASA, MASASHI OKADA1970 Volume 18 Issue 3 Pages 629-631
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (435K) -
SHOZO KAMIYA, GENZO OKUSA, HIROKO HIRAKAWA1970 Volume 18 Issue 3 Pages 632-633
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (363K) -
YUICHI KANAOKA, KOICHI MIYASHITA, OSAMU YONEMITSU1970 Volume 18 Issue 3 Pages 634-637
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (508K) -
OSAMU HOSHINO, HIROSHI HARA, MORITAKA WADA, BUNSUKE UMEZAWA1970 Volume 18 Issue 3 Pages 637-640
Published: March 25, 1970
Released on J-STAGE: March 31, 2008
JOURNAL FREE ACCESSDownload PDF (490K)
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