Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on 1-Alkyl-2 (1H)-pyridone Derivatives. XI. Reaction of 1-Methyl-2 (1H)-pyridone Derivatives with Formaldehyde and Hydrochloric Acid
HIROSHI TOMISAWAYUTAKA KOBAYASHIHIROSHI HONGOREIKO FUJITA
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1970 Volume 18 Issue 5 Pages 932-936

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Abstract
Reaction of 1-methyl-2 (1H)-pyridone with formaldehyde and hydrochloric acid was carried out. The products proved in this reaction were 5-hydroxymethyl-1-methyl-2 (1H)-pyridone (III) in 46% yield from 1-methyl-2 (1H)-pyridone (I), 5-ethyl-3-hydroxymethyl-1-methyl-2 (1H)-pyridone (VIII) from 5-ethyl-1-methyl-2 (1H)-pyridone (VII), and 6-hydroxymethyl-1-methyl-2 (1H)-quinolone (IX) from 1-methyl-2 (1H)-quinolone (II).
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© The Pharmaceutical Society of Japan
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