Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Studies on 1-Alkyl-2 (1H)-pyridone Derivatives. XII. Reaction of 2-Methyl-1 (2H)-isoquinolone with Formaldehyde and Hydrochloric Acid
HIROSHI TOMISAWAKUNIRO SAITOHIROSHI HONGOREIKO FUJITA
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1970 Volume 18 Issue 5 Pages 937-940

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Abstract
Reaction of 2-methyl-1 (2H)-isoquinolone (I) with formaldehyde and conc. hydrochloric acid was carried out and it was found that the product differed according to reaction conditions. The products obtained and their structure identified were 4-hydroxymethyl-2-methyl-1 (2H)-isoquinolone (II), 4, 4'-methylene-bis [2-methyl-1 (2H)-isoquinolone] (III), and 4-chloromethyl-2-methyl-1 (2H)-isoquinolone (IV).
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© The Pharmaceutical Society of Japan
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