Syntheses of the Urinary Metabolites of 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (Mepirizole, DA-398)

RENZO DOHMORI; RYUICHI YOSHIMURA; SHINICHI KITAHARA; YOSHIAKI TANAKA; TAKEO NAITO

doi:10.1248/cpb.18.1908

堂森廉三, 吉村龍一, 北原 [しん]一, 田中良明, 内藤武男

著者情報

ジャーナルフリー

1970 年 18 巻 9 号 p. 1908-1914

DOI https://doi.org/10.1248/cpb.18.1908

詳細

抄録

All the metabolites (UAM-1, UNM-1, UNM-2, UNM-4, and URM-1), which were isolated from the urine of rats and rabbits administered 1-(4-methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole (mepirizole, DA-398) were synthesized and their structures were established by direct comparison with the synthetic samples.

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