Abstract
Absorption, distribution and excretion of tritiated p-biphenylmethyl-(dl-tropyl-α-tropinium) bromide (3H-BTTB) in the rat were investigated. After the intravenous injection of 3H-BTTB, half life of the radioactivity in blood was 7 min at first 30 min. Higher radioactivities were incorporated in kidney, liver, pancreas and spleen. Almost negligible radioactivity was seen in amniotic fluid or fetus. After the intramuscular injection of 3H-BTTB, 6.62% and 60.16% of the radioactivity were excreted in urine and feces, respectively, at 96 hr. The fact may indicate that 3H-BTTB is mainly excreted in bile. It may be suggested that these behaviors in biological disposition are attributed to have a large molecular weight and to be a quaternary ammonium compound.
