Amino Acids and Peptides. II. A One-Step Synthesis of Atropine and Other Related Alkaloids from dl-Phenylalanine 3α-Tropanyl Ester
1971 年 19 巻 12 号 p. 2603-2608
詳細
1971 年 19 巻 12 号 p. 2603-2608
Atropine (VI), littorine (VII), apoatropine (IX), and related compounds have been synthesized by a one-step deamination reaction from dl-phenylalanine 3α-tropanyl ester (V). The amino ester (V) was obtained by coupling tropine with N-phthalyl-dl-phenylalanyl chloride (III) followed by hydrazinolysis with an equimolar amount of hydrazine hydrate.
