Studies on the Metabolic Fate and the Pharmacokinetics of 5-n-Butyl-1-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine (BCP) in Man. I. Identification of the Metabolites of BCP in Human Urine

抄録

Urinary metabolites of a non-steroidal anti-inflammatory drug, 5-n-butyl-1-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine (BCP) were investigated in man. Tow hydroxylated compounds, 1-cyclohexyl-5-(3-hydroxybutyl)-2, 4, 6-trioxoperhydropyrimidine (II) and 5-n-butyl-1-(4-hydroxycyclohexyl)-2, 4, 6-trioxoperhydropyrimidine (IV) were identified as the metabolites besides unchanged BCP, though two unknown minor peaks were observed by gas-liquid chromatography. The glucuronides or sulfates of II and IV were not detected clearly.