Various derivatives of 2-aryl-3-hydroxy-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (I) were synthesized. Alternative routes to 2-aryl-3-hydroxy-5-alkyl-trans-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (II-β) and 2-aryl-3-acetoxy-5-dimethylaminoethyl-cis-2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-one (VI-α) were also investigated respectively.
