Studies on Pyrimidine Derivatives and Related Compounds. LXX. A Novel Reaction of Thiamine Anhydride

Abstract

Reaction of thiamine Na salt with COS gave the compound having 1, 2-dithiolane ring (IV). This compound was readily obtained from the reaction of thiamine anhydride (I) and H₂S in DMF solution. Reaction of I with D₂S gave deuterium incorporated derivatives and the mechanism for the formation of IV was suggested.