Studies on the Metabolic Fate and the Pharmacokinetics of 5-n-Butyl-1-cyclohexy1-2, 4, 6-trioxoperhydropyrimidine (BCP) in Man. V. Pharmacokinetics of BCP in Man and in Rabbit following Intravenous Administration of BCPNa

Abstract

In order to support the application of the model 1 to simulate the behavior of 5-nbutyl-1-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine (BCP) in man, further studies were carried out independently in man and in rabbits.
The human plasma concentration and urinary excretion after the intravenous administration of BCPNa in a clinical test were simulated well by the model 1 with the same order of values for the rate constants as in the oral administration.
Then, using rabbits, BCP in organs and tissues along with the plasma concentration and urinary excretion were determined and compared with the simulated values by the model 1.
After correction for the mass balance, the tissue amounts of BCP were simulated fairly well.
These results indicated the applicability of the model 1 both in man and in rabbits.