Abstract
As an approach to the synthesis of mitomycin structure, 2-methoxy-10b, 11-dihydro-6H-isoindolo [2, 1-a] indole (X) and 2-methoxy-6H-isoindolo [2, 1-a] indole (XI) were synthesized. By the oxidative cyclization of 1-(2, 5-dihydroxybenzyl) isoindoline (VII) with alkaline potassium ferricyanide, a dihydroindole compound, 2-hydroxy-10b, 11-dihydro-6H-isoindolo [2, 1-a] indole (IX) was obtained as a main product beside a small amount of indole compound, 2-hydroxy-6H-isoindolo [2, 1-a] indole (VIII).
