Studies on Peptides. XXXII. The Use of N-Ethoxycarbonyl-2-ethoxy-1, 2-dihydro-quinoline as a Coupling Reagent of Peptide-Fragments on Polymer Support

Abstract

As an example of peptide-fragment condensation on the polymer support, coupling reaction between Z (OMe)-Val-Lys (Z)-Val-Tyr-Pro-OH (positions 19 to 24 of ACTH) and H-Asp (OBzl)-Gly-resin and H-Ala-Gly-resin was performed. Among various coupling reagents so far examined, N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline gave relatively good results.