抄録
Plasma levels of trimetazidine in rabbits, rats, and mice were determined. Plasma levels in animals showed unusual curve about 1 hr after oral administration and this reason was investigated by determining distribution of the drug in animal tissues and excretion of the drug in bile.
Metabolic pathways of trimetazidine in rabbits were investigated qualitatively and it was ascertained by thin-layer chromatography that the methylene group connecting the benzene and piperazine rings is not severed by metabolism in rabbits.
