Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Reaction of Biguanides and Related Compounds. IV. Reaction of Arylbiguanide with Benzoylacetone in the Presence of a Small Amount of the Arylbiguanide Hydrochloride
古川 潮小島 洋子林 清五郎
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1972 年 20 巻 5 号 p. 927-930

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Arylbiguanide reacted with benzoylacetone in the presence of proton to give eightmembered ring compound, 4-amino-2-arylamino-6-methyl-8-phenyl-1, 3, 5-triazacyclooctatetraen. p-Methoxyphenylbiguanide isolated exclusively two isomers, which were easily changed each other by heating. The structure of the compounds were discussed.

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© The Pharmaceutical Society of Japan
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