抄録
1. Urinary excretion of CHS-Na metabolites increased in rabbits and rats after prolonged administration of CHS-Na. 2. The metabolism of CHS-Na was investigated in rabbits pretreated with cyclo-hexylamine, cyclohexanone, or cyclohexanol and the urinary excretion of CHS-Na metabolites increased in the animals pretreated with cyclohexylamine or cyclohexanone. 3. The produced amounts of CHS-Na metabolites increased in the liver of CHS-Na-treated rabbit and scarcely changed in the liver of CHS-Na-treated rat. 4. The metabolism of cyclohexylamine showed an increase of urinary excretion of cyclohexylamine metabolites in rabbit and rat following prolonged administration of cyclohexylamine. On the other hand, the in vitro metabolism of cyclohexylamine resulted in an increase of cyclohexylamine metabolites in the liver of the cyclohexylaminetreated rabbit and did not show a conspicuous difference between the livers of control and the cyclohexylamine-treated rats. 5. These results demonstrated that prolonged administration of CHS-Na caused a stimulation of rabbit liver enzymes metabolizing CHS-Na and potentiated a certain process degrating CHS-Na in rat gut.
