Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Hypocholesterolemic Alkaloids of Lentinus edodes (BERK.) SING. IV. Synthesis of Three Stereoisomers of Eritadenine
MASASHI HASHIMOTOYOSHIHISA SAITOHIDEO SEKITAKASHI KAMIYA
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1972 Volume 20 Issue 7 Pages 1374-1379

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Abstract
The synthesis three stereoisomers of eritadenine (I) ; D-threo-(II), L-threo-(III) and L-eritadenine (IV), described. D-threo-Eritadenine (II) was derived from eritadenine by utilizing a novel ■thro-threo epimerization. L-threo-Eritadenine (II) was synthesized, starting from L-threonolactone dibenzoate (IX), through the route involving an imidazole ring closure. The synthesis of L-eritadenine (IV) was achieved conveniently by direct condensation of adenine and L-erythronolactone acetonide (XX).
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© The Pharmaceutical Society of Japan
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