Ring closure reactions for synthesizing 1-substituted 5-cyanouracils, 3-substituted 5-cyanouracils, 1-substituted 5-carboxyuracils and 1-substituted 5-acetyluracils were investigated where substitutents were methyl, butyl, phenyl, and cyclohexyl. These compounds were then methylated in 1-or 3-position to give 1, 3-disubstituted uracil derivatives which were useful as intermediates for drugs.
